diff --git a/.vpython3 b/.vpython3
index 467078621..53a62dd22 100644
--- a/.vpython3
+++ b/.vpython3
@@ -22,20 +22,20 @@
 # Read more about `vpython` and how to modify this file here:
 #   https://chromium.googlesource.com/infra/infra/+/main/doc/users/vpython.md
 
-python_version: "3.8"
+python_version: "3.11"
 
 # The default set of platforms vpython checks does not yet include mac-arm64.
 # Setting `verify_pep425_tag` to the list of platforms we explicitly must support
 # allows us to ensure that vpython specs stay mac-arm64-friendly
 verify_pep425_tag: [
-    {python: "cp38", abi: "cp38", platform: "manylinux1_x86_64"},
-    {python: "cp38", abi: "cp38", platform: "linux_arm64"},
+    {python: "cp311", abi: "cp311", platform: "manylinux1_x86_64"},
+    {python: "cp311", abi: "cp311", platform: "linux_arm64"},
 
-    {python: "cp38", abi: "cp38", platform: "macosx_10_10_intel"},
-    {python: "cp38", abi: "cp38", platform: "macosx_11_0_arm64"},
+    {python: "cp311", abi: "cp311", platform: "macosx_10_10_intel"},
+    {python: "cp311", abi: "cp311", platform: "macosx_11_0_arm64"},
 
-    {python: "cp38", abi: "cp38", platform: "win32"},
-    {python: "cp38", abi: "cp38", platform: "win_amd64"}
+    {python: "cp311", abi: "cp311", platform: "win32"},
+    {python: "cp311", abi: "cp311", platform: "win_amd64"}
 ]
 
 # Used by:
@@ -58,22 +58,11 @@ wheel: <
 # Chromium tests using Telemetry function properly.
 wheel: <
   name: "infra/python/wheels/numpy/${vpython_platform}"
-  version: "version:1.20.3"
-  # A newer version of numpy is required on ARM64, but it breaks older OS versions.
-  not_match_tag <
-    platform: "macosx_11_0_arm64"
-  >
->
-wheel: <
-  name: "infra/python/wheels/numpy/mac-arm64_cp38_cp38"
-  version: "version:1.21.1"
-  match_tag <
-    platform: "macosx_11_0_arm64"
-  >
+  version: "version:1.23.5.chromium.4"
 >
 wheel: <
   name: "infra/python/wheels/psutil/${vpython_platform}"
-  version: "version:5.8.0.chromium.2"
+  version: "version:5.9.8"
 >
 wheel: <
   name: "infra/python/wheels/requests-py3"
@@ -107,7 +96,7 @@ wheel: <
 >
 wheel: <
   name: "infra/python/wheels/python-dateutil-py2_py3"
-  version: "version:2.7.3"
+  version: "version:2.9.0"
 >
 
 # Used by WPT importer
@@ -223,12 +212,24 @@ wheel: <
   version: "version:1.4.0"
 >
 wheel: <
-  name: "infra/python/wheels/pillow/linux-amd64_cp38_cp38"
-  version: "version:8.1.2"
+  name: "infra/python/wheels/pillow/linux-amd64_cp311_cp311"
+  version: "version:10.4.0"
 >
 wheel: <
   name: "infra/python/wheels/aioquic/${vpython_platform}"
-  version: "version:0.9.15"
+  version: "version:1.2.0.chromium.1"
+>
+wheel: <
+  name: "infra/python/wheels/pyopenssl-py3"
+  version: "version:24.2.1"
+>
+wheel: <
+  name: "infra/python/wheels/service-identity-py3"
+  version: "version:24.1.0"
+>
+wheel: <
+  name: "infra/python/wheels/tzdata-py2_py3"
+  version: "version:2023.4"
 >
 wheel: <
   name: "infra/python/wheels/pylsqpack/${vpython_platform}"
@@ -236,11 +237,11 @@ wheel: <
 >
 wheel: <
   name: "infra/python/wheels/cryptography/${vpython_platform}"
-  version: "version:3.3.1.chromium.1"
+  version: "version:43.0.0"
 >
 wheel: <
   name: "infra/python/wheels/cffi/${vpython_platform}"
-  version: "version:1.14.5"
+  version: "version:1.15.1.chromium.2"
 >
 wheel: <
   name: "infra/python/wheels/pycparser-py2_py3"
@@ -323,14 +324,14 @@ wheel: <
 #   testing/buildbot/generate_buildbot_json_coveragetest.py
 wheel: <
   name: "infra/python/wheels/coverage/${vpython_platform}"
-  version: "version:5.5.chromium.2"
+  version: "version:7.3.1"
 >
 
 # Used by:
 #   //content/test/gpu
 wheel: <
   name: "infra/python/wheels/pathos/${vpython_platform}"
-  version: "version:0.2.7.chromium.4"
+  version: "version:0.3.0.chromium.2"
   not_match_tag <
     abi: "cp27mu"
     platform: "manylinux1_i686"
@@ -353,14 +354,14 @@ wheel: <
 #   //tools/infra/find_bad_builds.py
 wheel: <
   name: "infra/python/wheels/pytz-py2_py3"
-  version: "version:2018.4"
+  version: "version:2024.1"
 >
 
 # Used by:
 #   //third_party/blink/tools/blinkpy/web_tests/port/server_process.py
 wheel: <
   name: "infra/python/wheels/pywin32/${vpython_platform}"
-  version: "version:300"
+  version: "version:308"
   match_tag: <
     platform: "win32"
   >
@@ -373,7 +374,7 @@ wheel: <
 #   //content/test/gpu/gpu_tests/color_profile_manager_mac.py
 wheel: <
   name: "infra/python/wheels/pyobjc/${vpython_platform}"
-  version: "version:7.3.chromium.1"
+  version: "version:10.0"
   match_tag: <
     platform: "macosx_10_10_intel"
   >
@@ -390,7 +391,7 @@ wheel: <
 #   tools/perf/flakiness_cli
 wheel: <
   name: "infra/python/wheels/pandas/${vpython_platform}"
-  version: "version:1.3.2.chromium.1"
+  version: "version:2.2.3.chromium.1"
   match_tag: <
     platform: "win32"
   >