diff --git a/DEPS b/DEPS
index b33d5fa8d..f8ad0ccd9 100644
--- a/DEPS
+++ b/DEPS
@@ -5,7 +5,7 @@ gclient_gn_args = [
 
 vars = {
   'chromium_git': 'https://chromium.googlesource.com',
-  'chromium_revision': '1c174f8519b2926ff3e621467b6aa282b4934f4a',
+  'chromium_revision': '504c0697552240028c5412dafd2a7306a7cd4be7',
   'gn_version': 'git_revision:6f13aaac55a977e1948910942675c69f2b4f7a94',
   # ninja CIPD package version.
   # https://chrome-infra-packages.appspot.com/p/infra/3pp/tools/ninja
@@ -19,13 +19,13 @@ vars = {
 
 deps = {
   'src/build':
-    Var('chromium_git') + '/chromium/src/build' + '@' + '18e9d3c3adadf2489507e4e62afffafa46717d26',
+    Var('chromium_git') + '/chromium/src/build' + '@' + 'fe1231e1da1e95acb006f53d06caaad16756a376',
   'src/buildtools':
-    Var('chromium_git') + '/chromium/src/buildtools' + '@' + '33b52eafd539278600d34cd9ba23550d28c933d2',
+    Var('chromium_git') + '/chromium/src/buildtools' + '@' + '3c8fef071edb88facb7508060e978c5fb8608dd5',
   'src/testing':
-    Var('chromium_git') + '/chromium/src/testing' + '@' + 'aedf4723b9fcaf5a76164085f4a8e9797eee4bee',
+    Var('chromium_git') + '/chromium/src/testing' + '@' + 'b4dc828e84ae95e1f5bf855f040c065287dac335',
   'src/third_party':
-    Var('chromium_git') + '/chromium/src/third_party' + '@' + 'd6591989fa347099fd4c7d47ba8bf6ce900b4f8e',
+    Var('chromium_git') + '/chromium/src/third_party' + '@' + '73f7282fa28ca1fbe8401e391207fb6ccf34767f',
 
   'src/buildtools/linux64': {
     'packages': [
@@ -71,30 +71,30 @@ deps = {
   'src/buildtools/clang_format/script':
     Var('chromium_git') + '/external/github.com/llvm/llvm-project/clang/tools/clang-format.git' + '@' + '8b525d2747f2584fc35d8c7e612e66f377858df7',
   'src/buildtools/third_party/libc++/trunk':
-    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libcxx.git' + '@' + 'fc6bbc5eb039769b5ed2de84444a3c6f9b45a598',
+    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libcxx.git' + '@' + 'cd0a05047451dfbdef5ba85f97ac4888e432a377',
   'src/buildtools/third_party/libc++abi/trunk':
-    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libcxxabi.git' + '@' + '8dd405113a4f3694e910b79785dd7fb7535a888a',
+    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libcxxabi.git' + '@' + '1a32724f721e1c3b6c590a07fe4a954344f15e48',
   'src/buildtools/third_party/libunwind/trunk':
-    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libunwind.git' + '@' + 'aabcd8753678f1536e15eb6385a948470debdae4',
+    Var('chromium_git') + '/external/github.com/llvm/llvm-project/libunwind.git' + '@' + '5870472fdd17f33d923b02e3e0acb9cbb18dbc9a',
 
   'src/third_party/catapult':
-    Var('chromium_git') + '/catapult.git' + '@' + '3ffa6b222803f54188a7b249383b2f092a24d19a',
+    Var('chromium_git') + '/catapult.git' + '@' + '4efb51be8574f2969273012958eaae85d01ede0b',
   'src/third_party/colorama/src':
     Var('chromium_git') + '/external/colorama.git' + '@' + '799604a1041e9b3bc5d2789ecbd7e8db2e18e6b8',
   'src/third_party/depot_tools':
-    Var('chromium_git') + '/chromium/tools/depot_tools.git' + '@' + 'b52683fa2e74087464d32a1a9c76bf1b5275e4fe',
+    Var('chromium_git') + '/chromium/tools/depot_tools.git' + '@' + '2fc7e1ffd58b00601b47a5126201e5162911e244',
   'src/third_party/freetype/src':
-    Var('chromium_git') + '/chromium/src/third_party/freetype2.git' + '@' + 'dea2e6358b2f963008d447d27564dd79890b61f0',
+    Var('chromium_git') + '/chromium/src/third_party/freetype2.git' + '@' + '1c44de209cb465d175279dc30cd95f9857f703dd',
   'src/third_party/googletest/src':
     Var('chromium_git') + '/external/github.com/google/googletest.git' + '@' + 'af29db7ec28d6df1c7f0f745186884091e602e07',
   'src/third_party/harfbuzz-ng/src':
-    Var('chromium_git') + '/external/github.com/harfbuzz/harfbuzz.git' + '@' + '56c467093598ec559a7148b61e112e9de52b7076',
+    Var('chromium_git') + '/external/github.com/harfbuzz/harfbuzz.git' + '@' + '2822b589bc837fae6f66233e2cf2eef0f6ce8470',
   'src/third_party/libjpeg_turbo':
     Var('chromium_git') + '/chromium/deps/libjpeg_turbo.git' + '@' + 'ed683925e4897a84b3bffc5c1414c85b97a129a3',
   'src/third_party/nasm':
     Var('chromium_git') + '/chromium/deps/nasm.git' + '@' + '0873b2bae6a5388a1c55deac8456e3c60a47ca08',
   'src/tools':
-    Var('chromium_git') + '/chromium/src/tools' + '@' + 'a185bbc6c077438a59a89a97c6c6ae30895e976c',
+    Var('chromium_git') + '/chromium/src/tools' + '@' + 'a20d904d021175f221bf58921a5a67fd48420ed9',
 
   # libyuv-only dependencies (not present in Chromium).
   'src/third_party/gtest-parallel':
@@ -117,13 +117,13 @@ deps = {
       'dep_type': 'cipd',
   },
   'src/third_party/auto/src': {
-    'url': Var('chromium_git') + '/external/github.com/google/auto.git' + '@' + '3659a0e6436d3acfeda04e0bd1df3603f1e7ffac',
+    'url': Var('chromium_git') + '/external/github.com/google/auto.git' + '@' + '097f0ee6ffb0dc2a663d8afa0744ee1f230ae712',
     'condition': 'checkout_android',
   },
   'src/third_party/boringssl/src':
-    'https://boringssl.googlesource.com/boringssl.git' + '@' + '1ee71185a2322dc354bee5e5a0abfb1810a27dc6',
+    'https://boringssl.googlesource.com/boringssl.git' + '@' + 'f0518d45119dd4dd322a884669daf8247bc3c992',
   'src/base': {
-    'url': Var('chromium_git') + '/chromium/src/base' + '@' + '077682171b88d0aa0cb77a8e1cd4d959f58a20a3',
+    'url': Var('chromium_git') + '/chromium/src/base' + '@' + 'f80120ff3265ba9bcb27416cc489343cfdc8bc61',
     'condition': 'checkout_android',
   },
   'src/third_party/bazel': {
@@ -288,7 +288,7 @@ deps = {
   },
 
   'src/third_party/icu': {
-    'url': Var('chromium_git') + '/chromium/deps/icu.git' + '@' + 'da07448619763d1cde255b361324242646f5b268',
+    'url': Var('chromium_git') + '/chromium/deps/icu.git' + '@' + '1b7d391f0528fb3a4976b7541b387ee04f915f83',
   },
   'src/third_party/icu4j': {
       'packages': [
@@ -329,7 +329,7 @@ deps = {
     'condition': 'checkout_android',
   },
   'src/third_party/junit/src': {
-    'url': Var('chromium_git') + '/external/junit.git' + '@' + '64155f8a9babcfcf4263cf4d08253a1556e75481',
+    'url': Var('chromium_git') + '/external/junit.git' + '@' + '05fe2a64f59127c02135be22f416e91260d6ede6',
     'condition': 'checkout_android',
   },
   'src/third_party/libunwindstack': {
@@ -443,7 +443,7 @@ deps = {
 
   # iOS deps:
   'src/ios': {
-    'url': Var('chromium_git') + '/chromium/src/ios' + '@' + '211070da56a62cf7d2f7c7a81be29b57294c4343',
+    'url': Var('chromium_git') + '/chromium/src/ios' + '@' + '866ec86ecb27dad8a3ac7957590df7765a13834f',
     'condition': 'checkout_ios'
   },
 
@@ -2245,27 +2245,51 @@ hooks = [
     'condition': 'checkout_mac',
   },
   {
-    'name': 'msan_chained_origins',
+    'name': 'msan_chained_origins_focal',
     'pattern': '.',
     'condition': 'checkout_instrumented_libraries',
     'action': [ 'python3',
                 'src/third_party/depot_tools/download_from_google_storage.py',
-                "--no_resume",
-                "--no_auth",
-                "--bucket", "chromium-instrumented-libraries",
-                "-s", "src/third_party/instrumented_libraries/binaries/msan-chained-origins.tgz.sha1",
+                '--no_resume',
+                '--no_auth',
+                '--bucket', 'chromium-instrumented-libraries',
+                '-s', 'src/third_party/instrumented_libraries/binaries/msan-chained-origins-focal.tgz.sha1',
               ],
   },
   {
-    'name': 'msan_no_origins',
+    'name': 'msan_no_origins_focal',
     'pattern': '.',
     'condition': 'checkout_instrumented_libraries',
     'action': [ 'python3',
                 'src/third_party/depot_tools/download_from_google_storage.py',
-                "--no_resume",
-                "--no_auth",
-                "--bucket", "chromium-instrumented-libraries",
-                "-s", "src/third_party/instrumented_libraries/binaries/msan-no-origins.tgz.sha1",
+                '--no_resume',
+                '--no_auth',
+                '--bucket', 'chromium-instrumented-libraries',
+                '-s', 'src/third_party/instrumented_libraries/binaries/msan-no-origins-focal.tgz.sha1',
+              ],
+  },
+  {
+    'name': 'msan_chained_origins_xenial',
+    'pattern': '.',
+    'condition': 'checkout_instrumented_libraries',
+    'action': [ 'python3',
+                'src/third_party/depot_tools/download_from_google_storage.py',
+                '--no_resume',
+                '--no_auth',
+                '--bucket', 'chromium-instrumented-libraries',
+                '-s', 'src/third_party/instrumented_libraries/binaries/msan-chained-origins-xenial.tgz.sha1',
+              ],
+  },
+  {
+    'name': 'msan_no_origins_xenial',
+    'pattern': '.',
+    'condition': 'checkout_instrumented_libraries',
+    'action': [ 'python3',
+                'src/third_party/depot_tools/download_from_google_storage.py',
+                '--no_resume',
+                '--no_auth',
+                '--bucket', 'chromium-instrumented-libraries',
+                '-s', 'src/third_party/instrumented_libraries/binaries/msan-no-origins-xenial.tgz.sha1',
               ],
   },
   {