diff --git a/.vpython3 b/.vpython3
index 8b4b63f03..467078621 100644
--- a/.vpython3
+++ b/.vpython3
@@ -42,8 +42,8 @@ verify_pep425_tag: [
 #   build/android/pylib/local/emulator/avd.py
 #   components/policy/test_support/policy_testserver.py
 wheel: <
-  name: "infra/python/wheels/protobuf-py2_py3"
-  version: "version:3.15.8"
+  name: "infra/python/wheels/protobuf-py3"
+  version: "version:4.25.1"
 >
 
 # TODO(https://crbug.com/898348): Add in necessary wheels as Python3 versions