diff --git a/include/mbedtls/check_config.h b/include/mbedtls/check_config.h
index 1215e6eb95..040c1d2591 100644
--- a/include/mbedtls/check_config.h
+++ b/include/mbedtls/check_config.h
@@ -182,6 +182,16 @@
 #error "MBEDTLS_ENTROPY_FORCE_SHA256 defined, but not all prerequisites"
 #endif
 
+#if defined(__has_feature)
+#if __has_feature(memory_sanitizer)
+#define MBEDTLS_HAS_MEMSAN
+#endif
+#endif
+#if defined(MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN) &&  !defined(MBEDTLS_HAS_MEMSAN)
+#error "MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN requires building with MemorySanitizer"
+#endif
+#undef MBEDTLS_HAS_MEMSAN
+
 #if defined(MBEDTLS_TEST_NULL_ENTROPY) && \
     ( !defined(MBEDTLS_ENTROPY_C) || !defined(MBEDTLS_NO_DEFAULT_ENTROPY_SOURCES) )
 #error "MBEDTLS_TEST_NULL_ENTROPY defined, but not all prerequisites"
diff --git a/include/mbedtls/config.h b/include/mbedtls/config.h
index f08cc4a19e..0e7dc77d8d 100644
--- a/include/mbedtls/config.h
+++ b/include/mbedtls/config.h
@@ -444,6 +444,19 @@
 //#define MBEDTLS_ECP_RANDOMIZE_MXZ_ALT
 //#define MBEDTLS_ECP_NORMALIZE_MXZ_ALT
 
+/**
+ * \def MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
+ *
+ * Enable testing of the constant-flow nature of some sensitive functions with
+ * clang's MemorySanitizer. This causes some existing tests to also test
+ * non-functional properties of the code under test.
+ *
+ * This setting requires compiling with clang -fsanitize=memory.
+ *
+ * Uncomment to enable testing of the constant-flow nature of seletected code.
+ */
+//#define MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
+
 /**
  * \def MBEDTLS_TEST_NULL_ENTROPY
  *
diff --git a/library/version_features.c b/library/version_features.c
index 454c2be7f0..b5ac2da625 100644
--- a/library/version_features.c
+++ b/library/version_features.c
@@ -255,6 +255,9 @@ static const char *features[] = {
 #if defined(MBEDTLS_ECP_NORMALIZE_MXZ_ALT)
     "MBEDTLS_ECP_NORMALIZE_MXZ_ALT",
 #endif /* MBEDTLS_ECP_NORMALIZE_MXZ_ALT */
+#if defined(MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN)
+    "MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN",
+#endif /* MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN */
 #if defined(MBEDTLS_TEST_NULL_ENTROPY)
     "MBEDTLS_TEST_NULL_ENTROPY",
 #endif /* MBEDTLS_TEST_NULL_ENTROPY */
diff --git a/scripts/config.pl b/scripts/config.pl
index 87f59bc602..6153dd7a36 100755
--- a/scripts/config.pl
+++ b/scripts/config.pl
@@ -126,6 +126,7 @@ MBEDTLS_REMOVE_3DES_CIPHERSUITES
 MBEDTLS_REMOVE_ARC4_CIPHERSUITES
 MBEDTLS_RSA_NO_CRT
 MBEDTLS_SSL_HW_RECORD_ACCEL
+MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
 MBEDTLS_TEST_NULL_ENTROPY
 MBEDTLS_X509_ALLOW_UNSUPPORTED_CRITICAL_EXTENSION
 MBEDTLS_ZLIB_SUPPORT
diff --git a/tests/scripts/all.sh b/tests/scripts/all.sh
index 5de2f064df..f010af8c36 100755
--- a/tests/scripts/all.sh
+++ b/tests/scripts/all.sh
@@ -963,6 +963,18 @@ component_test_full_cmake_clang () {
     if_build_succeeded env OPENSSL_CMD="$OPENSSL_LEGACY" GNUTLS_CLI="$GNUTLS_LEGACY_CLI" GNUTLS_SERV="$GNUTLS_LEGACY_SERV" tests/compat.sh -e '^$' -f 'NULL\|DES\|RC4\|ARCFOUR'
 }
 
+component_test_memsan_constant_flow () {
+    msg "build: cmake memsan, full config with constant flow testing"
+    scripts/config.pl full
+    scripts/config.pl set MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN
+    scripts/config.pl unset MBEDTLS_AESNI_C # memsan doesn't grok asm
+    CC=clang cmake -D CMAKE_BUILD_TYPE:String=MemSan .
+    make
+
+    msg "test: main suites (memsan constant flow)"
+    make test
+}
+
 component_test_default_no_deprecated () {
     # Test that removing the deprecated features from the default
     # configuration leaves something consistent.
diff --git a/tests/suites/helpers.function b/tests/suites/helpers.function
index 96e18da169..2a6d34c014 100644
--- a/tests/suites/helpers.function
+++ b/tests/suites/helpers.function
@@ -38,6 +38,22 @@ typedef UINT32 uint32_t;
 #include <unistd.h>
 #endif
 
+#if defined(MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN)
+#include <sanitizer/msan_interface.h>
+
+/* Use macros to avoid messing up with origin tracking */
+#define TEST_CF_SECRET  __msan_allocated_memory
+// void __msan_allocated_memory(const volatile void* data, size_t size);
+#define TEST_CF_PUBLIC  __msan_unpoison
+// void __msan_unpoison(const volatile void *a, size_t size);
+
+#else /* MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN */
+
+#define TEST_CF_SECRET(ptr, size)
+#define TEST_CF_PUBLIC(ptr, size)
+
+#endif /* MBEDTLS_TEST_CONSTANT_FLOW_MEMSAN */
+
 /*----------------------------------------------------------------------------*/
 /* Constants */