diff --git a/tests/scripts/analyze_outcomes.py b/tests/scripts/analyze_outcomes.py
index 0266f1457c..f6921d5238 100755
--- a/tests/scripts/analyze_outcomes.py
+++ b/tests/scripts/analyze_outcomes.py
@@ -53,6 +53,15 @@ class CoverageTask(outcome_analysis.CoverageTask):
             # https://github.com/Mbed-TLS/mbedtls/issues/9581
             'Opaque key for server authentication: invalid key: decrypt with ECC key, no async',
             'Opaque key for server authentication: invalid key: ecdh with RSA key, no async',
+            # The following test fails intermittently on the CI with a frequency
+            # that significantly impacts CI throughput. They are thus disabled
+            # for the time being. See
+            # https://github.com/Mbed-TLS/mbedtls/issues/10652 for more
+            # information.
+            'DTLS proxy: 3d, openssl client, fragmentation',
+            'DTLS proxy: 3d, openssl client, fragmentation, nbio',
+            'DTLS proxy: 3d, gnutls client, fragmentation',
+            'DTLS proxy: 3d, gnutls client, fragmentation, nbio=2',
         ],
         'test_suite_config.mbedtls_boolean': [
             # We never test with CBC/PKCS5/PKCS12 enabled but
diff --git a/tests/ssl-opt.sh b/tests/ssl-opt.sh
index 509fb0e980..535388d902 100755
--- a/tests/ssl-opt.sh
+++ b/tests/ssl-opt.sh
@@ -13177,6 +13177,9 @@ run_test    "DTLS proxy: 3d, openssl client" \
             0 \
             -s "HTTP/1.0 200 OK"
 
+# The following test fails intermittently on the CI with a frequency that
+# significantly impacts CI throughput. Disable it for the time being.
+skip_next_test
 requires_openssl_next
 client_needs_more_time 8
 not_with_valgrind # risk of non-mbedtls peer timing out
@@ -13190,6 +13193,9 @@ run_test    "DTLS proxy: 3d, openssl client, fragmentation" \
             -s "found fragmented DTLS handshake message" \
             -s "Certificate handshake message has been buffered and reassembled"
 
+# The following test fails intermittently on the CI with a frequency that
+# significantly impacts CI throughput. Disable it for the time being.
+skip_next_test
 requires_openssl_next
 client_needs_more_time 8
 not_with_valgrind # risk of non-mbedtls peer timing out
@@ -13258,6 +13264,10 @@ run_test    "DTLS proxy: 3d, gnutls client" \
 # fragmentation to remain the case across GnuTLS version updates. Avoid using a
 # smaller MTU, as the smaller the MTU, the more likely the handshake is to fail
 # in this very unreliable connection emulation.
+
+# The following test fails intermittently on the CI with a frequency that
+# significantly impacts CI throughput. Disable it for the time being.
+skip_next_test
 requires_gnutls
 client_needs_more_time 8
 not_with_valgrind # risk of non-mbedtls peer timing out
@@ -13270,6 +13280,9 @@ run_test    "DTLS proxy: 3d, gnutls client, fragmentation" \
             -s "HTTP/1.0 200 OK" \
             -s "ClientHello handshake message has been buffered and reassembled"
 
+# The following test fails intermittently on the CI with a frequency that
+# significantly impacts CI throughput. Disable it for the time being.
+skip_next_test
 requires_gnutls
 client_needs_more_time 8
 not_with_valgrind # risk of non-mbedtls peer timing out